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Key Documents

SAB1400151

Sigma-Aldrich

Anti-LBR antibody produced in mouse

IgG fraction of antiserum, buffered aqueous solution

Synonyme(s) :

Anti-DHCR14B, Anti-LMN2R, Anti-MGC9041, Anti-PHA, Anti-PRO0650

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About This Item

Numéro MDL:
MFCD01634008
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

human

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect immunofluorescence: suitable
western blot: 1 μg/mL

Numéro d'accès UniProt

Q14739

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... LBR(3930)

Description générale

Lamin B receptor (LBR) is a transmembrane protein which is expressed in the inner nuclear membrane. It possesses an amino-terminal domain, eight transmembrane domains and a carboxyl-terminal region. The gene encoding LBR is localized on human chromosome 1q42.

Immunogène

LBR (NP_002287.2, 1 a.a. ~ 615 a.a) full-length human protein.

Sequence
MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSFRQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPLILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFSLSQESSYIATQYSLRPRREEVKLKEIDSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSLLNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFYAFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY

Actions biochimiques/physiologiques

Lamin B receptor (LBR) inhibits immature chromatin binding of proteins. It has a role in the construction of the nuclear envelope in vitro and in vivo. Mutation in the gene encoding LBR has been linked to Pelger-Huët anomaly (PHA).

Forme physique

Solution in phosphate buffered saline, pH 7.4

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

An in vitro model for Pelger-Huet anomaly: stable knockdown of lamin B receptor in HL-60 cells.
Olins AL
Nucleus (Austin, Tex.) (2010)
Shangming Tang et al.
Nature, 606(7916), 930-936 (2022-04-28)
Chromothripsis is a catastrophic mutational process that promotes tumorigenesis and causes congenital disease1-4. Chromothripsis originates from aberrations of nuclei called micronuclei or chromosome bridges5-8. These structures are associated with fragile nuclear envelopes that spontaneously rupture9,10, leading to DNA damage when
Dosage effect of zero to three functional LBRgenes
in vivo and in vitro
Sophia Gravemann
Nucleus (Austin, Tex.) (2010)
Temporal control of nuclear envelope assembly by phosphorylation of lamin B receptor.
Tseng LC and Chen RH
Molecular Biology of the Cell (2011)
Shiwei Liu et al.
Nature, 561(7724), 551-555 (2018-09-21)
Defects in the architecture or integrity of the nuclear envelope are associated with a variety of human diseases1. Micronuclei, one common nuclear aberration, are an origin for chromothripsis2, a catastrophic mutational process that is commonly observed in cancer3-5. Chromothripsis occurs
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