S3134

Streptokinase from β-hemolytic Streptococcus (Lancefield Group C)

lyophilized powder, ≥2,000 units/mg solid

• Synonyme(s) : Streptokinase from Streptococcus hemolyticus
• Numéro CAS: 9002-01-1
• Numéro de classification (Commission des enzymes): 3.4.99.0 (BRENDA, IUBMB)
• Numéro CE : 232-647-1
• Numéro MDL: MFCD00082037
• Code UNSPSC : 12352204
• eCl@ss : 32160410
• Nomenclature NACRES : NA.54

Propriétés

• Forme: lyophilized powder
• Niveau de qualité: 200
• Activité spécifique: ≥2,000 units/mg solid
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• InChI: 1S/C11H19NO2/c13-11(14)10-6-9(7-12-10)8-4-2-1-3-5-8/h8-10,12H,1-7H2,(H,13,14)
• Clé InChI: XRZWVSXEDRYQGC-UHFFFAOYSA-N

Description

Description générale

Research area: Cell signaling

Streptokinase is an extracellular enzyme produced by β-hemolytic Streptococcus. It is a single-chain polypeptide enzyme that consists of multiple structural domains, including α-, β-, and γ-domains.

Application

Streptokinase has been used in a study to compare primary coronary intervention and thrombolytic therapy in myocardial infarction patients.

Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare.

Actions biochimiques/physiologiques

Streptokinase is a potent plasminogen activator. Unlike human proteins tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), microbial streptokinase does not directly activate plasminogen. Instead, it activates plasminogen by fibrin-dependent and fibrin-independent. mechanisms. Streptokinase is effective in thrombolytic therapy. While streptokinase offers promising potential in treating ischemic stroke, its use also presents a significant risk of intracerebral hemorrhage. Streptokinase is also used in treating complicated parapneumonic effusions and empyema where allergic reactions, are rare.

Définition de l'unité

One unit is equal to the amount of activity in one unit from a Streptokinase International Standard reference vial.

Forme physique

Lyophilized powder containing ~50% total protein by biuret and sodium glutamate. Total protein composed of enzyme protein and human serum albumin.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable