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PZ0180

Sigma-Aldrich

Delavirdine mesylate

≥98% (HPLC)

Synonyme(s) :

N-[2-[[4-[3-[(1-Methylethyl)amino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]methanesulfonamide mesylate, Rescriptor

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About This Item

Formule empirique (notation de Hill):
C22H28N6O3S · CH3SO3H
Numéro CAS:
147221-93-0
Poids moléculaire :
552.67
Numéro MDL:
MFCD00866948
Code UNSPSC :
51111800
ID de substance PubChem :
329823754
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to tan

Pf

315 °C

Solubilité

DMSO: >5 mg/mL

Température de stockage

room temp

Chaîne SMILES 

CS(O)(=O)=O.CC(C)Nc1cccnc1N2CCN(CC2)C(=O)c3cc4cc(NS(C)(=O)=O)ccc4[nH]3

InChI

1S/C22H28N6O3S.CH4O3S/c1-15(2)24-19-5-4-8-23-21(19)27-9-11-28(12-10-27)22(29)20-14-16-13-17(26-32(3,30)31)6-7-18(16)25-20;1-5(2,3)4/h4-8,13-15,24-26H,9-12H2,1-3H3;1H3,(H,2,3,4)

Clé InChI

MEPNHSOMXMALDZ-UHFFFAOYSA-N

Actions biochimiques/physiologiques

Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It is used as part of highly active antiretroviral therapy (HAART) for the treatment of human immunodeficiency virus (HIV) type 1.

Caractéristiques et avantages

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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I-Chan Huang et al.
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 16(6), 1065-1072 (2007-04-07)
Most US studies that estimate EQ-5D index score generally apply the UK preference weights. We compared the validity of a newly-developed US weights to the UK weights for use of EQ-5D as a measure of health-related quality of life. Data
I-Chan Huang et al.
Health services research, 43(1 Pt 1), 327-339 (2008-01-24)
To compare different approaches to address ceiling effects when predicting EQ-5D index scores from the 10 subscales of the MOS-HIV Health Survey. Data were collected from an HIV treatment trial. Statistical methods included ordinary least squares (OLS) regression, the censored
E Lahner et al.
Alimentary pharmacology & therapeutics, 29(4), 379-386 (2008-12-05)
Impaired acid secretion may affect drug absorption and may be consequent to corporal Helicobacter pylori-gastritis, which may affect the absorption of orally administered drugs. To focus on the evidence of impaired drug absorption associated with H. pylori infection. Data sources
Vandna Munshi et al.
Analytical biochemistry, 374(1), 121-132 (2007-10-30)
Reverse transcriptase (RT) plays an essential role in the HIV-1 replication process, which converts a single-strand RNA into a double-strand DNA via polymerase and RNase H activities. Therefore, inhibition of RT has been one of the primary therapeutic strategies for
Qing Xia et al.
Protein science : a publication of the Protein Society, 16(8), 1728-1737 (2007-07-28)
Nonnucleoside reverse transcriptase inhibitors (NNRTI) are a group of structurally diverse compounds that bind to a single site in HIV-1 reverse transcriptase (RT), termed the NNRTI-binding pocket (NNRTI-BP). NNRTI binding to RT induces conformational changes in the enzyme that affect
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