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H0261

Sigma-Aldrich

DL-β-Hydroxybutyryl coenzyme A lithium salt

≥90%

Synonyme(s) :

DL-3- hydroxybutyryl Coenzyme A lithium salt

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About This Item

Formule empirique (notation de Hill):
C25H42N7O18P3S
Numéro CAS:
103404-51-9
Poids moléculaire :
853.62
Numéro MDL:
MFCD00079336
Code UNSPSC :
41106305
ID de substance PubChem :
24895396
Nomenclature NACRES :
NA.51

Source biologique

synthetic (Organic)

Niveau de qualité

200

Pureté

≥90%

Forme

powder

Solubilité

H2O: soluble-50 mg/mL, clear, colorless

Température de stockage

−20°C

Chaîne SMILES 

[Li].CC(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)n2cnc3c(N)ncnc23

InChI

1S/C25H42N7O18P3S.Li.H/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32;;/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41);;

Clé InChI

HNPHARRBSFXZAL-UHFFFAOYSA-N

Application

DL-β-Hydroxybutyryl coenzyme A lithium salt has been used:

  • as a substrate in the HSD17B4 protein enzymatic assay
  • as a substrate to determine the specificity and kinetics of Hc-DHS-28 and its mutation proteins
  • as a component of the reaction buffer in S-adenosyl-L-homocysteine hydrolase (AHCY) in vitro acylation

Actions biochimiques/physiologiques

3-Hydroxybutyryl coenzyme A (HBCoA) is converted to bacterial polyhydroxyalkanoates (PHB) by polyhydroxybutyrate (PHB) synthases. 3-Hydroxybutyryl coenzyme A is a substrate used to measure the specificity and kinetics of β-hydroxyacyl CoA dehydrogenase.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Consulter la Bibliothèque de documents

Ping Li et al.
Biochemistry, 48(39), 9202-9211 (2009-08-29)
Polyhydroxybutyrate (PHB) synthases catalyze the conversion of 3-hydroxybutyryl coenzyme A (HBCoA) to PHB with a molecular mass of 1.5 MDa. The class III synthase from Allochromatium vinosum is a tetramer of PhaEPhaC (each 40 kDa). The polymerization involves covalent catalysis
Kesaven Bhubalan et al.
Applied and environmental microbiology, 77(9), 2926-2933 (2011-03-15)
The synthesis of bacterial polyhydroxyalkanoates (PHA) is very much dependent on the expression and activity of a key enzyme, PHA synthase (PhaC). Many efforts are being pursued to enhance the activity and broaden the substrate specificity of PhaC. Here, we
Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury.
Cornille E, Abou-Hamdan M, et al.
BMC Neuroscience, 23, 51-51 (2010)
An Artemisinin Derivative ART1 Induces Ferroptosis by Targeting the HSD17B4 Protein Essential for Lipid Metabolism and Directly Inducing Lipid Peroxidation
Xie J, et al.
CCS Chemistry, 4(1), 304-317 (2022)
Yi Yang et al.
International journal for parasitology, 50(12), 945-957 (2020-08-29)
Haemonchus contortus could enter the diapause stage to avoid hostile conditions, however the inducing mechanism still remains poorly understood. A similar dauer strategy exists in Caenorhabditis elegans, and dauer phenomones, which are produced through a four step cycle of peroxisomal
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