E2387

NECA

≥98% (TLC), powder, adenosine receptor agonist

• Synonyme(s) : NECA
• Formule empirique (notation de Hill): C₁₂H₁₆N₆O₄
• Numéro CAS: 35920-39-9
• Poids moléculaire : 308.29
• Numéro MDL: MFCD00069195
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277684
• Nomenclature NACRES : NA.77

Propriétés

• product name: 5′-(N-Ethylcarboxamido)adenosine, powder
• Forme: powder
• Niveau de qualité: 200
• Couleur: white
• Solubilité: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL (Solutions may be stored for several days at 4 °C.); DMSO: 14 mg/mL (Solutions may be stored for several days at 4 °C.); 0.1 M HCl: 3.4 mg/mL (Solutions may be stored for several days at 4 °C.); H₂O: insoluble; ethanol: soluble (Solutions may be stored for several days at 4 °C.)
• Température de stockage: 2-8°C
• Chaîne SMILES: CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
• InChI: 1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1
• Clé InChI: JADDQZYHOWSFJD-FLNNQWSLSA-N
• Informations sur le gène: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) ; rat ... Adora1(29290) , Adora2a(25369) , Adora2b(29316) , Adora3(25370)

Description

Description générale

5′-(N-Ethylcarboxamido)adenosine stimulates vasodilation in the pulmonary circulation through A₂-adenosine-receptor activation.

Application

5′-(N-Ethylcarboxamido)adenosine has been used:

• for the purification of human adenosine A_2Areceptor (A_2AR) in decylmaltoside (DM)
• to determine nonspecific binding of adenosine receptors
• to investigate adenosine 2B receptor (RA2B) mechanism of action by competition assay

Actions biochimiques/physiologiques

Potent adenosine receptor agonist with nearly equal affinity at A₁ and A₂ receptors.

Caractéristiques et avantages

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H300
• Conseils de prudence: P264 - P301 + P310
• Classification des risques: Acute Tox. 2 Oral
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges