A0788

3-Aminobenzamide

≥99% (TLC)

• Synonyme(s) : 3-AB, 3-ABA
• Formule linéaire : H₂NC₆H₄CONH₂
• Numéro CAS: 3544-24-9
• Poids moléculaire : 136.15
• Numéro CE : 222-586-9
• Numéro MDL: MFCD00007989
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278206
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥99% (TLC)
• Forme: powder
• Couleur: white to off-white
• Pf: 115-116 °C (lit.)
• Solubilité: ethanol: 50 mg/mL, clear, light yellow; DMSO: soluble; H₂O: soluble (may require gentle heating)
• Température de stockage: room temp
• Chaîne SMILES: NC(=O)c1cccc(N)c1
• InChI: 1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)
• Clé InChI: GSCPDZHWVNUUFI-UHFFFAOYSA-N
• Informations sur le gène: mouse ... Parp1(11545)

Description

Application

3-Aminobenzamide has been used as a poly-(ADP-ribose) polymerase (PARP) inhibitor in various experimental studies.

Actions biochimiques/physiologiques

3-Aminobenzamide enhances cell death, unscheduled DNA synthesis and repair replication by interrupting the rejoining of DNA strand breaks induced by both ionizing radiations and several alkylating agents. It has an ability to inhibit the activity of nuclear enzyme poly (ADP-ribose) synthetase (PARS). 3-Aminobenzamide exhibits protective action against myocardial reperfusion injury and local inflammation.

Caractéristiques et avantages

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves