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Key Documents

336R-9

Sigma-Aldrich

Synaptophysin (MRQ-40) Rabbit Monoclonal Antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

MRQ-40, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions (See Chart)

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (336R-94)
vial of 0.5 mL concentrate (336R-95)
bottle of 1.0 mL predilute (336R-97)
vial of 1.0 mL concentrate (336R-96)
bottle of 7.0 mL predilute (336R-98)

Fabricant/nom de marque

Cell Marque™

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

Isotype

IgG1

Contrôle

pancreas

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

cytoplasmic

Informations sur le gène

human ... SYP(6855)

Description générale

Anti-synaptophysin reacts with neuroendocrine cells of the human adrenal medulla, pituitary,thyroid, lung, pancreas, and gastrointestinal mucosa. Positive staining is seen in neuronsof the brain. This antibody identifies normal neuroendocrine cells and neuroendocrineneoplasms. Diffuse, finely granular, cytoplasmic staining is observed, which probablycorrelates with the distribution of the antigen within neurosecretory vesicles. Antisynaptophysin is an independent, broad-range marker of neural and neuroendocrinedifferentiation.

Qualité


IVD
IVD
IVD
RUO

Liaison

Synaptophysin Positive Control Slides , Product No. 336S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Notes préparatoires

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Yasutaka Yamada et al.
Science translational medicine, 15(722), eadf6732-eadf6732 (2023-11-15)
Aberrant DNA methylation has been implicated as a key driver of prostate cancer lineage plasticity and histologic transformation to neuroendocrine prostate cancer (NEPC). DNA methyltransferases (DNMTs) are highly expressed, and global DNA methylation is dysregulated in NEPC. We identified that
M Skacel et al.
Applied immunohistochemistry & molecular morphology : AIMM, 8(3), 203-209 (2000-09-12)
Histologic differential diagnosis of acinar cell carcinoma (ACC), mixed acinar-endocrine cell carcinoma (MAEC), and pancreatic endocrine tumors (PET) can be difficult but is important because of differences in their clinical behavior. This study investigates the utility of immunohistochemistry (IHC) in
Eun-Ik Son et al.
Pathology international, 53(2), 67-73 (2003-02-18)
Medulloblastomas occurring in children represent a histological spectrum of varying anaplasia and nodularity. In order to determine whether immunohistochemical markers might be useful parameters in subclassifying these tumors, 17 pediatric medulloblastomas, including nine diffuse/non-anaplastic, four diffuse/anaplastic, three nodular/non-anaplastic and one
M H Lyda et al.
Human pathology, 31(8), 980-987 (2000-09-15)
The histologic classification of pulmonary neoplasms can have important implications regarding appropriate management of patients. Although the histologic classification of lung tumors is predominantly based on morphology, ancillary studies such as immunohistochemistry can be used in difficult cases, and the
T Kamisawa et al.
Pathology, research and practice, 192(9), 901-908 (1996-09-01)
To evaluate the significance of neuroendocrine differentiation in duct carcinoma of the pancreas, we investigated 79 pancreatic carcinomas, applying histochemistry and immunohistochemistry (chromogranin A, Leu-7, synaptophysin and neuron-specific enolase (NSE), and correlated the morphologic differentiation pattern with clinicopathological characteristics. There
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