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Y0000630

Paroxetine for system suitability

Name: Paroxetine for system suitability
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Paroxetine hydrochloride hemihydrate, (3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride hemihydrate

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About This Item

Formule empirique (notation de Hill):

C₁₉H₂₀FNO₃ · HCl · .5 H₂O

Numéro CAS:

110429-35-1

Poids moléculaire :

374.83

Numéro MDL:

MFCD03658863

Code UNSPSC :

41116107

ID de substance PubChem :

329831063

Nomenclature NACRES :

NA.24

Produits recommandés

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BP746

Paroxetine impurity standard

Y0000579

Paroxetine hydrochloride (anhydrous) impurity C

USP

1500218

Paroxetine hydrochloride

Supelco

PHR2835

Nilotinib Related compound C

USP

1500251

Paroxetine Related Compound D

Sigma-Aldrich

P9623

Paroxetine hydrochloride hemihydrate

Y0000580

Paroxetine impurity E

Y0000256

Paroxetine impurity D

Y0002167

Rosuvastatin impurity mixture

Y0000581

Paroxetine hydrochloride (anhydrous) impurity H

Qualité

pharmaceutical primary standard

Famille d'API

paroxetine

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES

O.Cl[H].Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3

InChI

1S/C19H20FNO3.ClH.H2O/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;/h1-6,9,14,17,21H,7-8,10-12H2;1H;1H2/t14-,17-;;/m0../s1

Clé InChI

QRQSGFFISBKLMZ-YHOFXEKLSA-N

Informations sur le gène

human ... SLC6A4(6532)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Paroxetine for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Paroxetine hydrochloride hemihydrate is one of the most potent and selective of the selective serotonin reuptake inhibitors (SSRI); antidepressant

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit

Description

Tarif

1500230

1500240

1500251

1500273

1500284

Y0000579

Paroxetine hydrochloride (anhydrous) impurity C, European Pharmacopoeia (EP) Reference Standard

PHR1804

Paroxetine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

BP1024

Paroxetine hydrochloride hemihydrate, British Pharmacopoeia (BP) Reference Standard

BP746

Paroxetine impurity standard, British Pharmacopoeia (BP) Reference Standard

1500207

PHR3076

PHR3077

Pictogrammes

GHS07,GHS09

Mention d'avertissement

Warning

Mentions de danger

H302,H317,H319,H335,H410

Conseils de prudence

P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Classification des risques

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Sens. 1 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

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Hyperreactive platelet phenotypes: relationship to altered serotonin transporter number, transport kinetics and intrinsic response to adrenergic co-stimulation.

Jeffrey S Berger et al.

Thrombosis and haemostasis, 109(1), 85-92 (2012-12-12)

The mechanism underlying a hyperreactive platelet phenotype remains unknown. Since serotonin has been shown to influence platelet biology and atherothrombosis, we sought to investigate the association of platelet serotonin transporter number, binding affinity, and uptake kinetics with platelet aggregation. A

Antidepressant use in pregnancy: a critical review focused on risks and controversies.

N Byatt et al.

Acta psychiatrica Scandinavica, 127(2), 94-114 (2012-12-18)

Conflicting data have led to controversy regarding antidepressant use during pregnancy. The objectives of this study are to i) review the risks of untreated depression and anxiety, ii) review the literature on risks of exposure to antidepressants during pregnancy, iii)

Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells.

Roi Isaac et al.

The Journal of biological chemistry, 288(8), 5682-5693 (2013-01-01)

Selective serotonin reuptake inhibitors (SSRIs) are antidepressants used for the treatment of mood and anxiety disorders. Here, we demonstrate that incubation (2 h) of murine islets or Min6 β cell line with the SSRIs paroxetine, fluoxetine, or sertraline inhibited insulin-induced

Paroxetine up-regulates neurogenesis in hippocampus-derived neural stem cell from fetal rats.

Zheng-Wu Peng et al.

Molecular and cellular biochemistry, 375(1-2), 105-113 (2013-01-08)

Paroxetine is a widely used antidepressant in clinic. Besides its role in inhibition of serotonin reuptake, resent studies indicate that the increase of hippocampal neurogenesis is also involved in its pharmacology. However, only limited data are available in this regard

A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans.

Jennifer C Naylor et al.

Psychiatry research, 206(2-3), 318-320 (2013-01-02)

Subthreshold posttraumatic stress disorder (PTSD) is associated with increased risk for suicidality, depression, and functional impairment. We thus conducted a small (N=12) pilot randomized controlled trial (RCT) with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) era

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