PHR1789

Doxorubicine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonyme(s) : DOX, Hydroxydaunorubicine hydrochloride
• Formule empirique (notation de Hill): C₂₇H₂₉NO₁₁ · HCl
• Numéro CAS: 25316-40-9
• Poids moléculaire : 579.98
• Numéro Beilstein : 4229251
• Numéro CE : 246-818-3
• Numéro MDL: MFCD00077757
• Code UNSPSC : 41116107
• ID de substance PubChem : 329823614
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material; pharmaceutical secondary standard
• Niveau de qualité: 300
• Agence: traceable to BP 990; traceable to Ph. Eur. D2975000; traceable to USP 1225703
• Famille d'API: doxorubicin
• Forme: powder
• CofA (certificat d'analyse): current certificate can be downloaded
• Conditionnement: pkg of 200 mg
• Technique(s): HPLC: suitable; gas chromatography (GC): suitable
• Pf: 216 °C (dec.) (lit.)
• Application(s): pharmaceutical (small molecule)
• Température de stockage: -10 to -25°C
• Chaîne SMILES: Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
• InChI: 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
• Clé InChI: MWWSFMDVAYGXBV-RUELKSSGSA-N
• Informations sur le gène: human ... TOP2A(7153)

Description

Description générale

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Doxorubicin Hydrochloride is an anthracycline antibiotic, known for its broad range anti-cancer activities.

Application

This pharmaceutical secondary standard can also be used as follows:

• Development of a reversed-phase high-performance liquid chromatographic (RP-HPLC) method combined with UV detection to determine doxorubicin hydrochloride in plasma samples
• Electrochemical determination of doxorubicin by spinel-structured cobalt ferrite (CoFe₂O₄) modified carbon paste electrode in biological fluid and injection samples
• Determination of doxorubicin hydrochloride in human plasma samples using a graphene quantum dots (GQDs) based electrochemical sensor
• RP-HPLC method-based quantitative analysis of doxorubicin hydrochloride in vacuum foam dried formulations
• Voltammetric determination of doxorubicin hydrochloride and dastinib using zinc oxide (ZnO) nanoparticle/1-butyl-3-methylimidazolium tetra-fluoroborate modified carbon paste electrode (ZnO-NPs/BMTFB/CPE) in their combined injection samples

Remarque sur l'analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Note de bas de page

To see an example of a Certificate of Analysis for this material enter LRAB3692 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Produits recommandés

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H340,H350,H360FD
• Conseils de prudence: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable