8.51014

Fmoc-OSu

≥99.0% (HPLC), for peptide synthesis, Novabiochem^®

• Synonyme(s) : Fmoc-OSu, FMOC-ONSu, N-(9H-Fluoren-9-ylmethoxycarbonyloxy)succinimide, N-(9-Fluorenylmethoxycarbonyloxy)succinimide, 9-Fluorenylmethyl-succinimidyl carbonate
• Formule empirique (notation de Hill): C₁₉H₁₅NO₅
• Numéro CAS: 82911-69-1
• Poids moléculaire : 337.33
• Numéro MDL: MFCD00010733
• Code UNSPSC : 12352108
• Numéro de classement CE : 433-520-5
• Nomenclature NACRES : NA.22

Propriétés

• product name: Fmoc-OSu, Novabiochem^®
• Niveau de qualité: 200
• Gamme de produits: Novabiochem^®
• Pureté: ≥99.0% (HPLC)
• Forme: powder
• Fabricant/nom de marque: Novabiochem^®
• Pf: 145-148 °C
• Application(s): peptide synthesis
• Groupe fonctionnel: Fmoc
• Température de stockage: 2-8°C
• InChI: 1S/C19H15NO5/c21-17-9-10-18(22)20(17)25-19(23)24-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2
• Clé InChI: WMSUFWLPZLCIHP-UHFFFAOYSA-N

Description

Description générale

Reagent for the preparation of pure Fmoc-amino acids that are free from contamination by Fmoc-dipeptides ^[1,2,3].

Literature references

^[1] A. Paquet (1982) Can. J. Chem., 60, 976.
^[2] L. Lapatsanis, et al. (1983) Synthesis, 671.
^[3] G. F. Sigler, et al. (1983) Biopolymers, 22, 2157.

Application

• Sequence-defined positioning of amine and amide residues to control catechol driven wet adhesion: This study uses Fmoc-OSu for selective functionalization of amines, demonstrating its role in synthesizing complex molecules with specific adhesive properties (Fischer et al., 2020).
• Fmoc-OASUD: A new reagent for the preparation of Fmoc-amino acids free from impurities resulting from Lossen rearrangement: Discusses the development of Fmoc-OASUD as a superior alternative to Fmoc-OSu, reducing impurities in peptide synthesis processes (Rao et al., 2016).

Liaison

Replaces: 01-63-0001

Remarque sur l'analyse

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

Informations légales

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H302 - H317 - H411
• Conseils de prudence: P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352
• Classification des risques: Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable