481407
NF-κB Activation Inhibitor
InSolution, ≥98%
Synonyme(s) :
InSolution NF-κB Activation Inhibitor
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About This Item
Formule empirique (notation de Hill):
C22H20N4O
Poids moléculaire :
356.42
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77
Produits recommandés
Niveau de qualité
Pureté
≥98% (HPLC)
Forme
liquid
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
OK to freeze
desiccated (hygroscopic)
protect from light
Conditions d'expédition
wet ice
Température de stockage
2-8°C
Description générale
A cell-permeable quinazoline compound that acts as a potent inhibitor of NF-κB transcriptional activation (IC50 = 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC50 = 7 nM in murine splenocytes). Does not exhibit cellular cytotoxicity even at concentrations as high as 10 µM. Reported to exhibit anti-inflammatory effects on carregeenin-induced paw edema in rats.
Actions biochimiques/physiologiques
Cell permeable: yes
Primary Target
NF-κB transcriptional activation
NF-κB transcriptional activation
Product does not compete with ATP.
Reversible: no
Target IC50: 11 nM against NF-κB transcriptional activation in Jurkat cells; 7 nM against LPS-induced TNF-α production in murine splenocytes
Conditionnement
Packaged under inert gas
Avertissement
Toxicity: Toxic (F)
Forme physique
A 10 mM (1 mg/281 µl) solution of NF-κB Activation Inhibitor (Cat. No. 481406) in DMSO.
Reconstitution
Following initial use, aliquot and refrigerate (4°C).
Autres remarques
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Tobe, M., et al. 2003. Bioorg. Med. Chem.11, 383.
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Point d'éclair (°C)
87 °C - closed cup - (Dimethylsulfoxide)
Certificats d'analyse (COA)
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation.
Masanori Tobe et al.
Bioorganic & medicinal chemistry, 11(3), 383-391 (2003-01-09)
We disclose here a new structural class of low-molecular-weight inhibitors of NF-kappa B activation that were designed and synthesized by starting from quinazoline derivative 6a. Structure-activity relationship (SAR) studies based on 6a elucidated the structural requirements essential for the inhibitory
Eunbi Ko et al.
Experimental dermatology, 24(12), 936-941 (2015-07-16)
House dust mites (HDMs) are known to trigger chronic inflammation through Toll-like receptors (TLRs) and their signalling cascades. In this study, we found that TLR2 ligation by HDMs induced the activation of dual oxidase 2 (Duox2) and nuclear factor-κB (NF-κB)
Differential regulation of transcription factor T-bet induction during NK cell development and T helper-1 cell differentiation.
Fang, et al.
Immunity, 55, 639-655 (2023)
Fatmah A Mansour et al.
Oncoimmunology, 9(1), 1729299-1729299 (2020-04-22)
The T-cell inhibitory molecule PD-L1 is expressed on a fraction of breast cancer cells. The distribution of PD-L1 on the different subpopulations of breast cancer cells is not well-defined. Our aim was to study the expression level of PD-L1 on
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