Accéder au contenu
Merck
Toutes les photos(1)

Key Documents

View All Documentation

860656P

Avanti

Lyso SM (d17:1)

Avanti Research™ - A Croda Brand 860656P, powder

Synonyme(s) :

Sphingosylphosphorylcholine (C17 base)

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Formule empirique (notation de Hill):
C22H47N2O5P
Numéro CAS:
118540-32-2
Poids moléculaire :
450.59
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Forme

powder

Conditionnement

pkg of 1 × 10 mg (860656P-10mg)
pkg of 1 × 5 mg (860656P-5mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 860656P

Type de lipide

sphingolipids

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

CCCCCCCCCCCC/C=C/[C@@]([H])(O)[C@@]([H])(N)COP([O-])(OCC[N+](C)(C)C)=O

Description générale

Lyso-sphingomyelin (Lyso SM) (d17:1), is an amphiphilic lysophospholipid with a long-chain sphingosine (C17 base) and a hydrophilic phosphorylcholine. Lyso SM, also known as sphingosylphosphorylcholine (SPC) is a de-acylated form of sphingomyelin, found in blood plasma.

Actions biochimiques/physiologiques

Lyso-sphingomyelin (Lyso SM) is a vital lipid mediator, with an ability to regulate cell proliferation, migration, differentiation, metabolism and apoptosis. It exhibits various functions in cardiovascular system, immune system, central nervous system and skin. Increased concentration of Lyso SM has been observed in few disease states such as atopic dermatitis, Niemann-Pick disease (NPD) and cancer.

Conditionnement

5 mL Amber Glass Screw Cap Vial (860656P-10mg)
5 mL Amber Glass Screw Cap Vial (860656P-5mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Code de la classe de stockage

11 - Combustible Solids

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Di Ge et al.
Acta pharmacologica Sinica, 39(12), 1830-1836 (2018-07-28)
Sphingosylphosphorylcholine (SPC) is a bioactive sphingolipid in blood plasma that is metabolized from the hydrolysis of the membrane sphingolipid. SPC maintains low levels in the circulation under normal conditions, which makes studying its origin and action difficult. In recent years
Wei-Lien Chuang et al.
Molecular genetics and metabolism, 111(2), 209-211 (2014-01-15)
Niemann-Pick disease type B (NPD-B) is caused by a partial deficiency of acid sphingomyelinase activity and results in the accumulation of lysosomal sphingomyelin (SPM) predominantly in macrophages. Notably, SPM is not significantly elevated in the plasma, whole blood, or urine
Hong-Wei Yue et al.
International journal of clinical and experimental medicine, 8(8), 11913-11921 (2015-11-10)
Sphingosylphosphorylcholine (SPC) is a naturally occurring bioactive sphingolipid in blood plasma, metabolizing from the hydrolysis of the membrane sphingolipid. It has been shown to exert multifunctional role in cell physiological regulation either as an intracellular second messenger or as an

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique