131303P
Avanti
Cerebrosides (Brain)
Avanti Research™ - A Croda Brand
Synonyme(s) :
Total Cerebrosides (Brain, Porcine)
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About This Item
Produits recommandés
Pureté
>99% (TLC)
Forme
powder
Conditionnement
pkg of 1 × 25 mg (131303P-25mg)
Fabricant/nom de marque
Avanti Research™ - A Croda Brand
Type de lipide
sphingolipids
Conditions d'expédition
dry ice
Température de stockage
−20°C
Description générale
Cerebrosides are glycosphingolipids with either glucose or galactose as a polar head group. They comprise the major component of the myelin lipids. Cerebrosides are part of non-neural cells including the epithelial cells associated with skin and the digestive system. Cerebrosides are amphipathic in nature.
The total brain cerebrosides appear as a double spot on thin layer chromatography (chloroform/methanol/water, 65:25:4 v/v). The top spot corresponds to ceresine which contain non-hydroxylated fatty acids, and the bottom spot corresponds to phrenosin which contain hydroxylated fatty acids.This Natural Lipid is a mixture and the structure shown above is only representative of one possible structure present in the product. Refer to chart for average fatty acid distribution.
Application
Cerebrosides (Brain) has been used:
- in the coating of coverslips for neurite outgrowth assay of retinal ganglion cells
- in reconstruction of the apical membrane of Madin-Darby canine kidney (MDCK) cells
- in the preparation of liposomes to mimic the MDCK cell membrane for permeability studies
Actions biochimiques/physiologiques
Cerebrosides regulate a variety of physiological processes like cell growth, survival and multiplication. They coordinate membrane trafficking and inhibit apoptosis. Inborn metabolic disorder, Gaucher′s disease is associated with elevated levels of cerebrosides.. Additionally, cerebrosides provide structural support to the membranes and mediate intracellular communication. Accumulation of galactocerebrosides is associated with tumors. It also serves as a receptor for human immune deficiency virus (HIV) glycoprotein. The porcine cerebroside and ganglioside (CPCG) is used in treating neurotoxicity induced by the drug oxaliplatin in digestive system tumors.
Conditionnement
5 mL Amber Glass Screw Cap Vial (131303P-25mg)
Informations légales
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Code de la classe de stockage
11 - Combustible Solids
Certificats d'analyse (COA)
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Les clients ont également consulté
Effects of compound porcine cerebroside and ganglioside on neurotoxicity caused by oxaliplatin chemotherapy: preliminary results.
Zhang YL, et al.
European Review for Medical and Pharmacological Sciences, 23(5), 5441-5448 (2019)
Direct visualization of the lateral structure of porcine brain cerebrosides/POPC mixtures in presence and absence of cholesterol
Fidorra M, et al.
Biophysical Journal, 97(1), 142-154 (2009)
The cerebrosides
Tan RX and Chen JH
Natural Product Reports, 20(5), 509-534 (2003)
Water permeability of asymmetric planar lipid bilayers: leaflets of different composition offer independent and additive resistances to permeation
Krylov AV, et al.
The Journal of General Physiology, 118(4), 333-340 (2001)
Reconstituting the barrier properties of a water-tight epithelial membrane by design of leaflet-specific liposomes
Hill WG and Zeidel ML
Test, 275(39), 30176-30185 (2000)
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