- A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans.
A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans.
Psychiatry research (2013-01-02)
Jennifer C Naylor, Trygve R Dolber, Jennifer L Strauss, Jason D Kilts, Timothy J Strauman, Daniel W Bradford, Steven T Szabo, Nagy A Youssef, Kathryn M Connor, Jonathan R T Davidson, Christine E Marx
PMID23276723
ABSTRACT
Subthreshold posttraumatic stress disorder (PTSD) is associated with increased risk for suicidality, depression, and functional impairment. We thus conducted a small (N=12) pilot randomized controlled trial (RCT) with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) era veterans. Hospital Anxiety and Depression Scale (HADS) scores improved by 30.4% in the paroxetine group. Paroxetine may have promise for subthreshold PTSD.
MATERIALS
Product Number
Brand
Product Description
Paroxetine for system suitability, European Pharmacopoeia (EP) Reference Standard
Paroxetine hydrochloride hemihydrate, European Pharmacopoeia (EP) Reference Standard
Supelco
Paroxetine maleate solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®