SML1596
PPZ2
≥98% (HPLC)
Synonym(s):
2-[4-(2,3-Dimethylphenyl)piperazin-1-yl]-N-(2-ethoxyphenyl)acetamide, 4-(2,3-Dimethylphenyl)-N-(2-ethoxyphenyl)-1-piperazineacetamide
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About This Item
Empirical Formula (Hill Notation):
C22H29N3O2
CAS Number:
Molecular Weight:
367.48
UNSPSC Code:
12352200
NACRES:
NA.25
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
PPZ2 selectively activates DAG-activated TRPC3/TRPC6/TRPC7 channels. PPZ2 activates native TRPC6-like channels in smooth muscle cells isolated from the rabbit portal vein. PPZ2 induces BDNF-like neurite growth and neuroprotection in cultured neurons.
TRPCs are cation channels, mainly permeable to Ca2+ ions. TRPC6 plays a crucial role in tumor development. TRPC3 controls fibronectin expression, thereby regulating wound healing process. TRPC7 is involved in the proliferation of osteoblasts.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Scientific reports, 5, 11620-11620 (2015-06-26)
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E Abed et al.
Cell proliferation, 40(6), 849-865 (2007-11-21)
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