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Dimethyl sulfone

Standard for quantitative NMR, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Synonym(s):

Methyl sulfone

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About This Item

Linear Formula:
(CH3)2SO2
CAS Number:
Molecular Weight:
94.13
Beilstein:
1737717
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

Standard for quantitative NMR
certified reference material
TraceCERT®

Quality Level

description

qNMR Standard for D2O and organic solvents (3.2 ppm)

product line

TraceCERT®

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

technique(s)

HPLC: suitable
gas chromatography (GC): suitable
qNMR: suitable

bp

238 °C (lit.)

mp

107-109 °C (lit.)

application(s)

cleaning products
cosmetics
environmental
flavors and fragrances
food and beverages
personal care
pharmaceutical

format

neat

SMILES string

CS(C)(=O)=O

InChI

1S/C2H6O2S/c1-5(2,3)4/h1-2H3

InChI key

HHVIBTZHLRERCL-UHFFFAOYSA-N

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General description

Dimethyl sulfone is a solvent, which can dissolve a wide range of solutes and can be generally used for high temperature reactions.
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com.

Check out our entire range of quantitative NMR standards (qNMR standards)

Application

Dimethyl sulfone has been used as internal standard, for the nuclear magnetic resonance spectrum studies of cocrystals containing API carbamazepine, synthesized using mechanochemical method of synthesis.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Other Notes

Chemical Shift: 3.2 ppm (chemical shifts may slightly vary depending on the experimental conditions)
suitable NMR solvents: D2O, DMSO-d6, CDCI3

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Legal Information

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Why are dimethyl sulfoxide and dimethyl sulfone such good solvents?
Clark T, et al.
Journal of Molecular Modeling, 14, 689-697 (2008)
Make and break-Facile synthesis of cocrystals and comprehensive dissolution studies
Batzdorf.L, et al.
Journal of Molecular Structure, 1133, 18-23 (2017)
Gaoqing Yuan et al.
Chemical communications (Cambridge, England), 48(60), 7513-7515 (2012-06-26)
With atmospheric oxygen as the oxidant, a novel copper(I)-catalyzed synthesis of aryl methyl sulfones from aryl halides and widely available DMSO is described. The procedure tolerates aryl halides with various functional groups (such as methoxy, acetyl, chloro, fluoro and nitro
M S Abdul Rasheed et al.
Poultry science, 99(12), 6559-6568 (2020-11-30)
A 28-day experiment was conducted in broilers to study the effects of feeding methylsulfonylmethane (MSM) and IL-10-neutralizing antibody from dried egg product (DEP) on the growth performance, immune responsivity, oxidative stress parameters, and gut health outcomes during a mild infection
Eytan M Debbi et al.
BMC complementary and alternative medicine, 11, 50-50 (2011-06-29)
Patients with osteoarthritis (OA) take a variety of health supplements in an attempt to reduce pain and improve function. The aim of this study was to determine the efficacy of methylsulfonylmethane (MSM) in treating patients with knee OA. This study

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