33226

Glycine

puriss. p.a., reag. Ph. Eur., buffer substance, 99.7-101% (calc. to the dried substance)

• Synonym(s): Aminoacetic acid, Aminoethanoic acid, Glycocoll
• Linear Formula: NH₂CH₂COOH
• CAS Number: 56-40-6
• Molecular Weight: 75.07
• Beilstein: 635782
• EC Number: 200-272-2
• MDL number: MFCD00008131
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 57648780
• NACRES: NA.21

Properties

• Agency: USP/NF; reag. Ph. Eur.
• Quality Level: 200
• grade: puriss. p.a.
• Assay: 99.7-101% (calc. to the dried substance)
• form: crystalline powder
• technique(s): IR spectroscopy: suitable
• impurities: ≤0.001% heavy metals (as Pb); ≤0.02% ammonium (NH₄); ≤0.1% water (Karl Fischer); ≤1.0% ninhydrin-positive substances
• ign. residue: ≤0.05% (as SO₄)
• loss: ≤0.5% loss on drying, 105°C, 2 h
• pH: 5.9-6.4 (20 °C, 5%)
• pKa (25 °C): (1) 2.35, (2) 9.60; 2.35
• mp: 240 °C (dec.) (lit.)
• anion traces: chloride (Cl^-): ≤30 mg/kg; sulfate (SO₄^2-): ≤20 mg/kg
• cation traces: Fe: ≤5 mg/kg
• suitability: in accordance for identity (IR)
• SMILES string: NCC(O)=O
• InChI: 1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
• InChI key: DHMQDGOQFOQNFH-UHFFFAOYSA-N
• Gene Information: rat ... Grin2a(24409)

Description

Application

Glycine can be used as:

• A reactant in the natural soil clay-catalyzed cleavage and polycondensation with pyrogallol.
• A catalyst in the Knoevenagel reaction between aryl aldehydes and malononitrile to form a C=C bond.
• A reagent in the metal-free synthesis of biaryls from aryl sulfoxides and sulfonanilides via sigmatropic rearrangement.

Biochem/physiol Actions

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves