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  • HDL quality or cholesterol cargo: what really matters--spotlight on sphingosine-1-phosphate-rich HDL.

HDL quality or cholesterol cargo: what really matters--spotlight on sphingosine-1-phosphate-rich HDL.

Current opinion in lipidology (2013-05-09)
Emmanuel E Egom, Mamas A Mamas, Handrean Soran
ABSTRACT

The absolute level of HDL cholesterol (HDL-C) may not be the only criterion contributing to their antiatherothrombotic effects. This review focuses on evidence in support of the concept that HDL-bound sphingosine-1-phosphate (S1P) plays a role in different HDL atheroprotective properties and may represent a potential target for therapeutic interventions. Recent large randomized clinical trials testing the hypothesis of raising HDL-C with niacin and dalcetrapib in statin-treated patients failed to improve cardiovascular outcomes. Emerging evidence suggests that many of the cardioprotective functions of HDL, such as vasodilation, angiogenesis and endothelial barrier function, protection against ischemia/reperfusion injury, and inhibition of atherosclerosis, may be attributable to its S1P cargo. HDL-associated S1P may represent a future therapeutic target. HDL functionality is affected by its composition and there is evidence to suggest S1P plays a role in some of HDL's functions and atheroprotective properties.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Sphingosine 1-phosphate, ≥98.0% (TLC)
Sigma-Aldrich
Sphingosine 1-phosphate, ≥95%, powder