- MIC values of voriconazole are predictive of treatment results in murine infections by Aspergillus terreus species complex.
MIC values of voriconazole are predictive of treatment results in murine infections by Aspergillus terreus species complex.
Antimicrobial agents and chemotherapy (2013-01-09)
Valentina Salas, F Javier Pastor, Deanna A Sutton, Enrique Calvo, Emilio Mayayo, Annette W Fothergill, Michael G Rinaldi, Josep Guarro
PMID23295929
ABSTRACT
We evaluated the efficacy of voriconazole against nine strains of Aspergillus terreus with different MICs (0.12 to 4 μg/ml) by using a murine model. Markers of efficacy included survival, tissue burden, galactomannan antigenemia, and drug serum levels. Voriconazole was especially effective in prolonging survival and reducing the fungal load in infections by strains that showed MICs that were less than or equal to the epidemiological cutoff value (1 μg/ml). In vitro data might be useful for predicting the outcome of A. terreus infections.
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