B1502
Brain Extract from bovine brain
Type I, Folch Fraction I
Synonym(s):
Brain Extract from Bovine
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About This Item
Recommended Products
biological source
bovine brain
type
Type I
form
powder
lipid type
phosphoglycerides
storage temp.
−20°C
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General description
Brain extract has lipids, especially polyunsaturated fatty acids (PUFAs) at high level. Extract from substantia niagra and the striatum has high amount of iron.
Application
Brain Extract from bovine brain has been used:
- to prepare small unilamellar vesicles
- in lipid binding assay
- to aid the recovery of phosphoinositides and also to terminate the reaction in phosphatidylinositol 5-phosphate (PtdIns5P) and PtdIns4P assay
- in liposome and protein self-aggregation assays
Biochem/physiol Actions
Brain lipids are involved in cellular signal transduction, membrane organization, trafficking protein modification, interactions and energy storage.
Packaging
Sealed ampule.
Components
Contains phosphatidylinositol phosphatidylserine,other brain lipids.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Structure and dynamics of helix-0 of the N-BAR domain in lipid micelles and bilayers
Biophysical Journal, 95(9), 4315-4323 (2008)
Measurement of phosphoinositides in the zebrafish Danio rerio
Nature Protocols, 8(6), 1058-1058 (2013)
Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity
The Journal of Neuroscience, 26, 2380-2390 (2006)
Cholesterol and Fat Metabolism in Alzheimer?s Disease
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders, 161-193 (2017)
Biochemistry, 51(2), 586-596 (2011-12-02)
PICK1 (protein interacting with C kinase 1) contains an N-terminal protein binding PDZ domain and a C-terminal lipid binding BAR domain. PICK1 plays a key role in several physiological processes, including synaptic plasticity. However, little is known about the cellular
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