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  • Discovery of novel hydroxy-thiazoles as HIF-alpha prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation.

Discovery of novel hydroxy-thiazoles as HIF-alpha prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation.

Bioorganic & medicinal chemistry letters (2008-06-27)
Christopher M Tegley, Vellarkad N Viswanadhan, Kaustav Biswas, Michael J Frohn, Tanya A N Peterkin, Catherine Chang, Roland W Bürli, Jennifer H Dao, Henrike Veith, Norma Rogers, Sean C Yoder, Gloria Biddlecome, Philip Tagari, Jennifer R Allen, Randall W Hungate
PMID18579373
ABSTRACT

Inhibition of the PHD2 enzyme has been associated with increased red blood cell levels. From a screening hit, a series of novel hydroxyl-thiazoles were developed as potent PHD2 inhibitors.