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The role of iron and reactive oxygen species in cell death.

The role of iron and reactive oxygen species in cell death.

Nature chemical biology (2013-12-19)

Scott J Dixon, Brent R Stockwell

ABSTRACT

The transition metal iron is essential for life, yet potentially toxic iron-catalyzed reactive oxygen species (ROS) are unavoidable in an oxygen-rich environment. Iron and ROS are increasingly recognized as important initiators and mediators of cell death in a variety of organisms and pathological situations. Here, we review recent discoveries regarding the mechanism by which iron and ROS participate in cell death. We describe the different roles of iron in triggering cell death, targets of iron-dependent ROS that mediate cell death and a new form of iron-dependent cell death termed ferroptosis. Recent advances in understanding the role of iron and ROS in cell death offer unexpected surprises and suggest new therapeutic avenues to treat cancer, organ damage and degenerative disease.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Iron, puriss. p.a., carbonyl-Iron powder, low in magnesium and manganese compounds, ≥99.5% (RT)

Iron, IRMM^®, certified reference material, 0.5 mm wire

Sigma-Aldrich

Iron, foil, thickness 0.1 mm, ≥99.9% trace metals basis

Sigma-Aldrich

Iron, powder, −325 mesh, 97%

Sigma-Aldrich

Iron, chips, 99.98% trace metals basis

Sigma-Aldrich

Iron, wire, diam. 0.5 mm, ≥99.9% trace metals basis

Iron, foil, light tested, 25x25mm, thickness 0.05mm, hard, 99.5%

Iron, foil, 6mm disks, thickness 0.5mm, hard, 99.5%

Iron, foil, 50mm disks, thickness 0.25mm, hard, 99.5%

Iron, foil, light tested, 100x100mm, thickness 0.025mm, as rolled, 99.99+%

Iron, foil, 8mm disks, thickness 0.05mm, as rolled, 99.99+%

Iron, foil, not light tested, 100x100mm, thickness 0.003mm, 99.85%

Iron, foil, 6mm disks, thickness 0.125mm, hard, 99.5%

Iron, foil, not light tested, 100x100mm, thickness 0.005mm, 99.85%

Iron, foil, 50mm disks, thickness 0.38mm, hard, 99.5%

Iron, foil, light tested, 25x25mm, thickness 0.075mm, hard, 99.5%

Iron, foil, 6mm disks, thickness 0.020mm, 99.85%

Iron, foil, light tested, 100x100mm, thickness 0.025mm, hard, 99.5%

Iron, foil, 6mm disks, thickness 0.125mm, as rolled, 99.99+%

Iron, foil, 8mm disks, thickness 0.05mm, hard, 99.5%

Iron, foil, 6mm disks, thickness 0.15mm, hard, 99.5%

Iron, foil, not light tested, 100x100mm, thickness 0.007mm, 99.85%

Iron, foil, 6mm disks, thickness 0.007mm, 99.85%

Iron, foil, 50mm disks, thickness 0.5mm, hard, 99.5%

Iron, foil, 8mm disks, thickness 0.020mm, 99.85%

Iron, foil, light tested, 300x300mm, thickness 0.075mm, hard, 99.5%

Iron, foil, 8mm disks, thickness 0.38mm, hard, 99.5%

Iron, foil, 8mm disks, thickness 0.003mm, 99.85%

Iron, foil, 6mm disks, thickness 0.004mm, 99.85%

Iron, foil, 50mm disks, thickness 0.1mm, hard, 99.5%