Natural products in parallel synthesis: triazole libraries of nonactic acid.

Bioorganic & medicinal chemistry letters (2008-07-01)

Sarah B Luesse, Gregg Wells, Abhijit Nayek, Adrienne E Smith, Brian R Kusche, Stephen C Bergmeier, Mark C McMills, Nigel D Priestley, Dennis L Wright

ABSTRACT

The synthesis of a library of nonactic acid-derived triazoloamide derivatives and their evaluation as antimicrobial agents is described.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Nonactin, from Streptomyces griseus, ≥98.0% (Total homologs, HPLC)

Sigma-Aldrich

Nonactin, from Streptomyces sp., ≥97.0% (TLC)

Sigma-Aldrich

Ammonium ionophore I, Selectophore^™, function tested, ≥98.0% ((Total homologs), HPLC)