- Multicomponent asymmetric reactions mediated by proline lithium salt.
Multicomponent asymmetric reactions mediated by proline lithium salt.
Organic & biomolecular chemistry (2010-02-19)
Polyssena Renzi, Jacob Overgaard, Marco Bella
PMID20165783
ABSTRACT
The multicomponent reaction between proline lithium salt, 2-cyclohexen-1-one and aliphatic aldehydes affords the 4-alkylidene-2-cyclohexen-1-ones, which are interesting fragrances, and bicyclic amino acids that bear four additional stereocenters, obtained as single stereoisomer.