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  • Total synthesis of (-)-conocarpan and assignment of the absolute configuration by chemical methods.

Total synthesis of (-)-conocarpan and assignment of the absolute configuration by chemical methods.

Chemical communications (Cambridge, England) (2007-05-24)
Derrick L J Clive, Elia J L Stoffman
ABSTRACT

(-)-Conocarpan (1) was synthesized by a method based on radical cyclization, and the absolute configuration was established by chemical degradation; the original 2R,3R-assignment to (+)-conocarpan should be reversed, as suggested by a later chiroptical study of model 2,3-dihydrobenzofurans.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2,3-Dihydrobenzofuran, 99%
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