Yes, the milligram quantities listed for the package sizes is correct. The packaged product is not available in gram quantities.
M4145
Minoxidil
Minoxidil
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≥99% (TLC), powder, androgenetic alopecia drug
Synonym(s):
6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide, 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide
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25 MG
£74.40
100 MG
£117.00
250 MG
£379.00
500 MG
£801.00
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25 MG
£74.40
100 MG
£117.00
250 MG
£379.00
500 MG
£801.00
About This Item
Empirical Formula (Hill Notation):
C9H15N5O
CAS Number:
Molecular Weight:
209.25
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Product Name
Minoxidil, ≥99% (TLC)
Quality Level
Assay
≥99% (TLC)
mp
272-274 °C (dec.) (lit.)
originator
Johnson & Johnson
SMILES string
NC1=CC(=NC(=N)N1O)N2CCCCC2
InChI
1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
InChI key
ZIMGGGWCDYVHOY-UHFFFAOYSA-N
Gene Information
human ... KCNJ1(3758)
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Application
Minoxidil has been used as test drug:
- in dermal papilla spheroid model, to study the effect of hair regeneration[1]
- administered orally to experimental rats, in the approach to identify biomarkers of drug induced vascular injury[2]
- administered via oral gavage to nonhuman primate model in order to study its effect on tilt responses[3]
Biochem/physiol Actions
Minoxidil is originally used to treat hypertension, which also induces hypertrichosis. It is considered as a potent drug for treating androgenetic alopecia.[4]
Activates ATP-activated K+ channels; vasodilator; slow or stop hair loss and promote hair regrowth.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Establishment of an in vitro organoid model of dermal papilla of human hair follicle
Gupta AC, et al.
Journal of Cellular Physiology, 233(11), 9015-9030 (2018)
J van der Velden et al.
Cellular and molecular life sciences : CMLS, 55(5), 788-798 (1999-06-24)
To investigate whether during cardiac hypertrophy changes occur in contractile protein composition and in mechanical and energetic properties of the myocardium, contractile protein composition, isometric force and adenosine triphosphate (ATP) consumption were studied in control and hypertrophied guinea-pig hearts. Cardiac
C Löffler-Walz et al.
British journal of pharmacology, 123(7), 1395-1402 (1998-05-14)
1. The binding of [3H]-P1075, a potent opener of adenosine-5'-triphosphate-(ATP)-sensitive K+ channels, was studied in a crude heart membrane preparation of the rat, at 37 degrees C. 2. Binding required MgATP. In the presence of an ATP-regenerating system, MgATP supported
J I Kourie
The Journal of membrane biology, 164(1), 47-58 (1998-06-24)
The lipid bilayer technique was used to examine the effects of the ATP-sensitive K+ channel inhibitor (glibenclamide) and openers (diazoxide, minoxidil and cromakalim) and Cl- channel activators (GABA and diazepam) on two types of chloride channels in the sarcoplasmic reticulum
A non-human primate model for investigating drug-induced risk of orthostatic hypotension and sympathetic dysfunction: Preclinical correlate to a clinical test
Bhatt S, et al.
Journal of Pharmacological and Toxicological Methods, 73(2), 49-55 (2015)
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Hi، Is the unit of measurement correctly written in milligrams? Shouldn't it have been written gram?
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