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About This Item
Empirical Formula (Hill Notation):
C54H85N13O15S
CAS Number:
Molecular Weight:
1188.40
MDL number:
UNSPSC Code:
12352200
Assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
CCC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C2CCCN2C(=O)C3CCC(=O)N3)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(N)=O
Amino Acid Sequence
pGlu-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2
Biochem/physiol Actions
Tachykinin originally isolated from the salivary gland of octopus with structural homology to substance P; potent vasodilator and hypotensive agent; induces salivation and increases capillary permeability. Agonist at tachykinin NK-2/NK-3 receptors.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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C Makridis et al.
Journal of gastroenterology and hepatology, 14(5), 500-507 (1999-06-04)
Diarrhoea is an important feature of the carcinoid syndrome, and various agents which may be released from carcinoid tumours have been considered to contribute pathophysiologically. The aim of the present study was to determine luminal concentrations of possible chemical mediators
S Kar et al.
The Journal of comparative neurology, 354(2), 253-281 (1995-04-03)
A number of neuroactive peptides including calcitonin gene-related peptide (CGRP), substance P, neurokinin B, opioids, somatostatin (SRIF), galanin, neurotensin and vasoactive intestinal polypeptide (VIP) have been localized in adult rat spinal cord and are considered to participate either directly and/or
P Pompei et al.
Peptides, 14(1), 97-102 (1993-01-01)
The present study evaluated the sensitivity of spontaneously hypertensive (SHR) and of Wistar Kyoto (WKY) rats to the hypotensive effect of tachykinins (TKs). Eledoisin, substance P, and the NK-1-selective agonist [Sar9,Met(O2)11]substance P evoked a smaller hypotensive response in SHR than
G Hölzemann et al.
International journal of peptide and protein research, 44(2), 105-111 (1994-08-01)
The synthesis of 11 cyclic hexapeptides, some of which contain a carbohydrate side chain moiety, is described in this paper. A glycosylamine was coupled without hydroxyl protecting groups either directly or via a butyric acid spacer to the side chain
U Gether et al.
The Journal of biological chemistry, 268(11), 7893-7898 (1993-04-15)
The NK1 (substance P) and NK3 (neurokinin B) receptors are G protein-coupled receptors sharing approximately 70% identity within the membrane-spanning domains. However, they each have a distinct pharmacological profile in respect of peptide binding. To identify epitopes that determine their
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