SREBF1
sterol regulatory element binding transcription factor 1
Synonyms:
SREBP-1c, SREBP1, bHLHd1
Species:
Human SREBF1 (6720), Mouse Srebf1 (20787), Rat Srebf1 (78968), chicken SREBF1 (373915), domestic cat SREBF1 (101087535), dog SREBF1 (403475), Horse SREBF1 (100052283), sheep SREBF1 (100329218), Goat SREBF1 (100860908), cow SREBF1 (539361) ...More
UniProtKB ID:
Gene ID:
- Human(6720) Summary: This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(20787) sterol regulatory element binding transcription factor 1
- Rat(78968) sterol regulatory element binding transcription factor 1
- chicken(373915) sterol regulatory element binding transcription factor 1
- domestic cat(101087535) sterol regulatory element binding transcription factor 1
- dog(403475) sterol regulatory element binding transcription factor 1
- Horse(100052283) sterol regulatory element binding transcription factor 1
- sheep(100329218) sterol regulatory element binding transcription factor 1
- Goat(100860908) sterol regulatory element binding transcription factor 1
- cow(539361) sterol regulatory element binding transcription factor 1
- domestic guinea pig(100731641) sterol regulatory element binding transcription factor 1
- naked mole-rat(101705277) sterol regulatory element binding transcription factor 1
- Zebrafish(793274) sterol regulatory element binding transcription factor 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-SREBP-1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-SREBF1, (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
dog, goat, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-phospho-SREBP-1 (pSer439) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
ANTI-SREBF1 antibody produced in mouse, clone 4G4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-SREBF1 (AB1) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
western blot