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Merck

PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

Synonyms:
COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS
Species:
Human PTGS1 (5742), Mouse Ptgs1 (19224), Rat Ptgs1 (24693), chicken PTGS1 (427752), Zebrafish ptgs1 (246226), naked mole-rat Ptgs1 (101698854), dog PTGS1 (403544), sheep PTGS1 (443551), Horse PTGS1 (100034087), domestic cat PTGS1 (101092557) ...More
UniProtKB ID:
P23219, A8K1V7, B4DHQ2, Q15122, Q5T7T6, Q5T7T7, Q5T7T8
Gene ID:
  • Human(5742) Summary: This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
  • Mouse(19224) prostaglandin-endoperoxide synthase 1
  • Rat(24693) prostaglandin-endoperoxide synthase 1
  • chicken(427752) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • Zebrafish(246226) prostaglandin-endoperoxide synthase 1
  • naked mole-rat(101698854) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • dog(403544) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • sheep(443551) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • Horse(100034087) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • domestic cat(101092557) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • domestic guinea pig(100714030) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • cow(282022) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB2500266
Anti-COX1/PTGS1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
AV41836
Anti-PTGS1 (AB1) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, guinea pig, horse, human, mouse, rat, sheep
Application
immunohistochemistry
western blot
HPA002834
Anti-Anti-PTGS1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
SAB1406337
Anti-PTGS1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
SAB4502490
Anti-COX1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
10784
Antipyrine, tested according to Ph. Eur.,
Species
human
N0630
Niflumic acid, ,
Species
human
A5882
Antipyrine, analytical standard,
Species
human
1040005
Antipyrine, United States Pharmacopeia (USP) Reference Standard,
Species
human
P0800000
Phenazone, European Pharmacopoeia (EP) Reference Standard,
Species
human

esiRNA

Product Number
Description
Species
EMU077371
MISSION® esiRNA, targeting mouse Ptgs1,
Species
mouse
EHU074281
MISSION® esiRNA, targeting human PTGS1,
Species
human