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ATP1A1

ATPase, Na+/K+ transporting, alpha 1 polypeptide

Synonyms:
Species:
UniProtKB ID:
Gene ID:
  • Human(476) Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
  • Mouse(11928) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • Rat(24211) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • domestic cat(101083695) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • Horse(100034139) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • dog(403992) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • chicken(396530) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • Domestic Rabbit(100302415) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • sheep(443381) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • cow(282144) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • naked mole-rat(101697634) ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • domestic guinea pig(100192382) ATPase, Na+/K+ transporting, alpha 1 polypeptide

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Small Molecule - Activator

Product Number
Description
Species
Digitoxigenin, ,
Species
rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Phospho-ATP1A1-S16 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-ATP1A1 (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot
Anti-Na+/K+ ATPase alpha-3, from rabbit,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-ATP1 α antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
rat
Application
ELISA
immunofluorescence

western blot
Anti-ATPASE antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Melittin, ≥97% (HPLC), synthetic,
Species
mouse, rat, human
Digitoxin, European Pharmacopoeia (EP) Reference Standard,
Species
human
Digitoxin, United States Pharmacopeia (USP) Reference Standard,
Species
human
Digitoxin, ≥92% (HPLC), powder,
Species
human
Digoxin solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human

Proteins

Product Number
Description
Species
Adenosine 5′-Triphosphatase from porcine cerebral cortex, lyophilized powder, ≥0.3 units/mg protein, pH 7.8,
Species

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human ATP1A1,
Species
human
MISSION® esiRNA, targeting mouse Atp1a1,
Species
mouse