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Merck

ABL1

c-abl oncogene 1, non-receptor tyrosine kinase

Synonyms:
ABL, JTK7, bcr/abl, c-ABL, p150, v-abl
Species:
UniProtKB ID:
Gene ID:
  • Human(25) Summary: The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008]
  • Mouse(11350) c-abl oncogene 1, non-receptor tyrosine kinase
  • Rat(311860) c-abl oncogene 1, non-receptor tyrosine kinase
  • chicken(417181) c-abl oncogene 1, non-receptor tyrosine kinase
  • domestic cat(101087622) c-abl oncogene 1, non-receptor tyrosine kinase
  • Zebrafish(100000720) c-abl oncogene 1, receptor tyrosine kinase
  • cow(540876) c-abl oncogene 1, non-receptor tyrosine kinase
  • naked mole-rat(101724428) c-abl oncogene 1, non-receptor tyrosine kinase
  • Horse(100069715) c-abl oncogene 1, non-receptor tyrosine kinase
  • domestic guinea pig(100720976) c-abl oncogene 1, non-receptor tyrosine kinase
  • dog(491292) c-abl oncogene 1, non-receptor tyrosine kinase
  • sheep(101122941) c-abl oncogene 1, non-receptor tyrosine kinase

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-ABL1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
Species Reactivity
human
Application
immunohistochemistry
Anti-ABL1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Anti-ABL1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab2,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Anti-ABL antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-phospho-c-Abl (pTyr412) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Nilotinib, ,
Species
human
Imatinib, ,
Species
human
Bosutinib, ≥98% (HPLC),
Species
human
Dasatinib, ,
Species
human
Dasatinib, ≥98% (HPLC),
Species
human

Proteins

Product Number
Description
Species
ABL1, active, His tagged human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
ABL1 (27-end), active, His-tagged from mouse, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
mouse

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Abl1,
Species
mouse
MISSION® esiRNA, targeting human ABL1,
Species
human