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  • Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale.

Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale.

Zeitschrift fur Naturforschung. C, Journal of biosciences (2015-05-29)
Pedro Aqueveque, Carlos Leonardo Céspedes, José Becerra, Marcelo Dávila, Olov Sterner
ABSTRACT

Liquid fermentations of the fungus Stereum rameale (N° 2511) yielded extracts with antibacterial activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 μg/mL), Bacillus subtilis (10 μg/mL) and Staphylococcus aureus (100 μg/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 μg/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 μg/mL, respectively.

MATERIALS
Product Number
Brand
Product Description

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