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  • The mucosal inflammatory response to non-typhoidal Salmonella in the intestine is blunted by IL-10 during concurrent malaria parasite infection.

The mucosal inflammatory response to non-typhoidal Salmonella in the intestine is blunted by IL-10 during concurrent malaria parasite infection.

Mucosal immunology (2014-03-29)
J P Mooney, B P Butler, K L Lokken, M N Xavier, J Y Chau, N Schaltenberg, S Dandekar, M D George, R L Santos, S Luckhart, R M Tsolis
ABSTRACT

Coinfection can markedly alter the response to a pathogen, thereby changing its clinical presentation. For example, non-typhoidal Salmonella (NTS) serotypes are associated with gastroenteritis in immunocompetent individuals. In contrast, individuals with severe pediatric malaria can develop bacteremic infections with NTS, during which symptoms of gastroenteritis are commonly absent. Here we report that, in both a ligated ileal loop model and a mouse colitis model, malaria parasites caused a global suppression of gut inflammatory responses and blunted the neutrophil influx that is characteristic of NTS infection. Further, malaria parasite infection led to increased recovery of Salmonella enterica serotype Typhimurium from the draining mesenteric lymph node (MLN) of mice. In the mouse colitis model, blunted intestinal inflammation during NTS infection was independent of anemia but instead required parasite-induced synthesis of interleukin (IL)-10. Blocking of IL-10 in coinfected mice reduced dissemination of S. Typhimurium to the MLN, suggesting that induction of IL-10 contributes to development of disseminated infection. Thus IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS, which may contribute to differences in the clinical presentation of NTS infection in the setting of malaria.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Quinine hemisulfate salt monohydrate, BioReagent, suitable for fluorescence, 99.0-101.0%
Sigma-Aldrich
Quinine hemisulfate salt monohydrate, tested according to Ph. Eur.
Sigma-Aldrich
Quinine hemisulfate salt monohydrate, synthetic, ≥90% (HPLC)
Quinine sulfate, meets USP testing specifications, monograph mol wt. 782.94 ((C20H24N2O2)2 . H2SO4 . 2H2O)