Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Cancer letters (2012-10-04)

Himashinie V K Diyabalanage, Michael L Granda, Jacob M Hooker

ABSTRACT

One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in vivo in recent studies for many cancer types and stages. In this review, we discuss the most commonly used combinations of histone deacetylase inhibitors and platinum based drugs in the context of their possible mechanisms, efficiency, efficacy, and related drawbacks in preclinical and clinical studies.

MATERIALS

Product Number

Brand

Product Description

685453

Sigma-Aldrich

Platinum, nanopowder, <50 nm particle size (TEM)

204048

Sigma-Aldrich

Platinum, powder (coarse), 99.99% trace metals basis

298107

Sigma-Aldrich

Platinum, gauze, 52 mesh, 99.9% trace metals basis

204013

Sigma-Aldrich

Platinum, powder, 99.995% trace metals basis

303798

Sigma-Aldrich

Platinum, foil, thickness 0.05 mm, ≥99.9% trace metals basis

357359

Sigma-Aldrich

Platinum, wire, diam. 0.20 mm, ≥99.99% trace metals basis

267163

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.99% trace metals basis

267155

Sigma-Aldrich

Platinum, sponge, ≥99.9% trace metals basis

267171

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.99% trace metals basis

327492

Sigma-Aldrich

Platinum, wire, diam. 1.0 mm, 99.9% trace metals basis

357367

Sigma-Aldrich

Platinum, wire, diam. 0.10 mm, 99.99% trace metals basis

349372

Sigma-Aldrich

Platinum, foil, thickness 1.0 mm, 99.99% trace metals basis

373265

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, thermocouple grade

349399

Sigma-Aldrich

Platinum, wire, diam. 1.5 mm, ≥99.9% trace metals basis

349364

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.99% trace metals basis

349356

Sigma-Aldrich

Platinum, foil, thickness 0.05 mm, 99.99% trace metals basis

267260

Sigma-Aldrich

Platinum, foil, thickness 0.5 mm, 99.99% trace metals basis

327433

Sigma-Aldrich

Platinum, foil, thickness 0.125-0.135 mm, 99.9% trace metals basis

267228

Sigma-Aldrich

Platinum, wire, diam. 0.5 mm, 99.9% trace metals basis

267201

Sigma-Aldrich

Platinum, wire, diam. 0.5 mm, 99.99% trace metals basis

373214

Sigma-Aldrich

Platinum, evaporation slug, diam. × L 0.6 cm × 1.2 cm, 99.99% trace metals basis

GF29479438

Platinum, foil, 0.05m coil, thickness 0.15mm, coil width .9mm, as rolled, 99.99%

GF90133376

Platinum, rod, 25mm, diameter 3.0mm, 99.95%

GF91422132

Platinum, foil, 0.1m coil, thickness 0.05mm, coil width 1mm, as rolled, 99.99%

GF34217276

Platinum, foil, 15mm disks, thickness 0.05mm, as rolled, 99.95%

GF70707911

Platinum, foil, 0.05m coil, thickness 0.025mm, coil width 5mm, as rolled, 99.95%

GF27192359

Platinum, tube, 1000mm, outside diameter 0.5mm, inside diameter 0.42mm, wall thickness 0.04mm, as drawn, 99.95%

GF04974880

Platinum, wire reel, 0.05m, diameter 0.5mm, as drawn, 99.99+%

GF43477117

Platinum, tube, 50mm, outside diameter 0.40mm, inside diameter 0.16mm, wall thickness 0.12mm, as drawn, 99.95%

GF56820157

Platinum, foil, 4mm disks, thickness 0.0125mm, as rolled, 99.95%