Organic-inorganic macroion coacervate complexation.

Coacervate complexes that are liquid-liquid separated complex materials are often formed by stoichiometrically mixing oppositely charged polyelectrolytes in salted aqueous solution. Entropy-driven ion pairing, resulting from the release of counterions near polyelectrolytes, has been identified as the primary driving force for coacervate formation between oppositely charged polyelectrolytes, including proteins and DNA, in aqueous solution. In this work we have examined the complexation between net neutral zwitterionic poly(sulfobetaine methacrylate) (PSBMA) and inorganic polyoxometalate (POM) polyanions in LiCl aqueous solutions. Biphasic liquid-like coacervate complexes can be formed over a much broader range of POM-to-PSBMA molar ratio and LiCl concentration than that for conventional polyelectrolyte coacervate complexation. Composition analysis of the dried supernatant and dense coacervate has confirmed that both PSBMA and POM macroions are primarily present in the dense coacervate as the macroion-rich phase in contrast to the presence of LiCl solely in the supernatant as the macroion-poor phase. The increase of net charge negativity of PSBMA and supernatant conductivity suggests stronger binding of PSBMA with POM anions than monovalent Cl