Contribution of inducible and neuronal nitric oxide synthases to mitochondrial damage and melatonin rescue in LPS-treated mice.

Contribution of inducible and neuronal nitric oxide synthases to mitochondrial damage and melatonin rescue in LPS-treated mice.

Journal of physiology and biochemistry (2017-01-23)

José Antonio García, Francisco Ortiz, Javier Miana, Carolina Doerrier, Marisol Fernández-Ortiz, Iryna Rusanova, Germaine Escames, José Joaquín García, Darío Acuña-Castroviejo

PMID28110436

RÉSUMÉ

NOS isoform activation is related to liver failure during sepsis, but the mechanisms driving mitochondrial impairment remain unclear. We induced sepsis by LPS administration to inducible nitric oxide synthase (iNOS