A novel redox regulator, MnTnBuOE-2-PyP

A novel redox regulator, MnTnBuOE-2-PyP

Redox biology (2017-02-24)

Y Zhao, D W Carroll, Y You, L Chaiswing, R Wen, I Batinic-Haberle, S Bondada, Y Liang, D K St Clair

RÉSUMÉ

The signaling of reactive oxygen species (ROS) is essential for the maintenance of normal cellular function. However, whether and how ROS regulate stem cells are unclear. Here, we demonstrate that, in transgenic mice expressing the human manganese superoxide dismutase (MnSOD) gene, a scavenger of ROS in mitochondria, the number and function of mouse hematopoietic stem/progenitor cells (HSPC) under physiological conditions are enhanced. Importantly, giving MnTnBuOE-2-PyP

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Adenosine 5′-triphosphate (ATP) bioluminescent somatic cell assay kit, for cellular ATP determination