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Merck

A concise total synthesis of (+/-)-acutifolone A.

Organic & biomolecular chemistry (2009-07-31)
Ming-Tsang Hsieh, Hsing-Jang Liu, Tai Wei Ly, Kak-Shan Shia
RÉSUMÉ

Starting from 4-methylcyclohexanone (7), a concise total synthesis of the pinguisane-type sesquiterpenoid acutifolone A, in racemic form, has been accomplished in 14 steps with an overall yield of 14.5%.

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Sigma-Aldrich
4-Methylcyclohexanone, 99%