- Carnitine conjugate of nipecotic acid: a new example of dual prodrug.
Carnitine conjugate of nipecotic acid: a new example of dual prodrug.
Molecules (Basel, Switzerland) (2009-09-29)
Carmela Napolitano, Martina Scaglianti, Emanuela Scalambra, Stefano Manfredini, Luca Ferraro, Sarah Beggiato, Silvia Vertuani
PMID19783924
RÉSUMÉ
As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.