Transition-metal-free atropo-selective synthesis of biaryl compounds based on arynes.

Transition-metal-free atropo-selective synthesis of biaryl compounds based on arynes.

Chemistry (Weinheim an der Bergstrasse, Germany) (2012-09-29)

Frédéric R Leroux, Anaïs Berthelot, Laurence Bonnafoux, Armen Panossian, Françoise Colobert

PMID23019081

RÉSUMÉ

A modular way towards biaryls: Highly enantioenriched biphenyls can be prepared based on a transition-metal-free aryl-aryl coupling followed by efficient desymmetrization or deracemization and chemoselective functionalization (see scheme).

MATÉRIAUX

Référence du produit

Marque

Description du produit

W312908

Sigma-Aldrich

Biphenyl, ≥99%

B34656

Sigma-Aldrich

Biphenyl, ReagentPlus^®, 99.5%

S9652

Sigma-Aldrich

Safrole, ≥97%

35800

Supelco

Biphenyl, PESTANAL^®, analytical standard

08010

Supelco

Safrole, certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland