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Bactericidal activity of topical antiseptics and their gargles against Bordetella pertussis.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (2011-10-05)
Takahisa Suzuki, Hiroshi Kataoka, Takashi Ida, Kazunari Kamachi, Takeshi Mikuniya
RÉSUMÉ

Bordetella pertussis is the etiological agent of whooping cough, a common cause of respiratory illness in both children and adults. In the present study, we investigated the bactericidal activity of four antiseptics-povidone-iodine (PVP-I), benzethonium chloride (BEC), chlorhexidine gluconate (CHG) and benzalkonium chloride (BAC)-against B. pertussis ATCC9797 and clinical isolates. Among the topical antiseptics, PVP-I, BEC, and BAC, PVP-I and BAC in particular, showed high bactericidal activity, whereas CHG had low activity. PVP-I gargle also showed high bactericidal activity, similar to topical PVP-I. However, BEC gargle had low bactericidal activity. Our results indicate that topical PVP-I and BAC, and PVP-I gargle would be useful as effective antiseptics against B. pertussis.

MATÉRIAUX
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Description du produit

Sigma-Aldrich
Benzethonium chloride, ≥97% (titration), ≥98% (HPLC)
Sigma-Aldrich
Hyamine® 1622 solution, 4 mM in H2O
Sigma-Aldrich
Benzethonium chloride, BioUltra, ≥99.0% (AT)