- Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives.
Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives.
Bioorganic & medicinal chemistry (2011-09-10)
Dengfeng Dou, Deepu Alex, Bingfan Du, Kok-Chuan Tiew, Sridhar Aravapalli, Sivakoteswara Rao Mandadapu, Richard Calderone, William C Groutas
PMID21903403
RÉSUMÉ
A series of broad-spectrum antifungal agents based on the 1,2-benzisothiazol-3(2H)-one scaffold is reported. Preliminary structure-activity relationship studies have established the importance of the presence of the heterocyclic ring, a methyl group, and a phenyl ring for optimal manifestation of antifungal activity.