Glycosylation reaction via a mild and efficient one-pot reaction using doped natural phosphate with iodine as catalyst.

Glycosylation reaction via a mild and efficient one-pot reaction using doped natural phosphate with iodine as catalyst.

Nucleosides, nucleotides & nucleic acids (2007-12-07)

H B Lazrek, D Ouzebla, L Baddi, J J Vasseur

RÉSUMÉ

Several alpha/beta-D-ribonucleosides were synthesized in good yields under mild conditions by N-glycosylations of acetyl 2,3,5-tri-O-benzoyl-beta-D-ribofuranose with silylated nucleobases in acetonitrile using NP doped with iodine as catalyst.

MATÉRIAUX

Référence du produit

Marque

Description du produit

225770

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Lithium bis(triméthylsilyl)amide solution, 1.0 M in THF

440191

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245585

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Sodium bis(trimethylsilyl)amide solution, 1.0 M in THF

702722

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Potassium bis(triméthylsilyl)amide solution, 1 M in THF

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Hexaméthyldisilazane, ReagentPlus^®, 99.9%

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Supelco

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