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Regioselective Suzuki-Miyaura reaction: application to the microwave-promoted synthesis of 4,7-diarylquinazolines.

Molecules (Basel, Switzerland) (2010-07-27)
Youssef Kabri, Pierre Verhaeghe, Armand Gellis, Patrice Vanelle
RÉSUMÉ

New diarylquinazolines displaying pharmaceutical potential were synthesized in high yields from 4,7-dichloro-2-(2-methylprop-1-enyl)-6-nitroquinazoline by using microwave-promoted regioselective Suzuki-Miyaura cross-coupling reactions.

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Sigma-Aldrich
2-Amino-4-chlorobenzonitrile, 99%