- Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase.
Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase.
Bioorganic & medicinal chemistry letters (2008-04-25)
Yuli Xie, Yidong Liu, Gangli Gong, Alison Rinderspacher, Shi-Xian Deng, Deborah H Smith, Udo Toebben, Effie Tzilianos, Lars Branden, Dusica Vidović, Caty Chung, Stephan Schürer, Lutz Tautz, Donald W Landry
PMID18434147
RÉSUMÉ
We report here a class of thiazolidine-2,4-diones and 2-thioxothiazolidin-4-ones as potent inhibitors of the lymphoid specific tyrosine phosphatase (Lyp) identified from high throughput screens. Chemical modification by incorporating the known phosphotyrosine (pTyr) mimics led to the discovery of a salicylate-based inhibitor with submicromolar potency.
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