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SML0258

Sigma-Aldrich

CPPG

≥98% (HPLC)

Synonyme(s) :

(R,S)-α-Cyclopropyl-4-phosphonophenylglycine

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About This Item

Formule empirique (notation de Hill):
C11H14NO5P
Numéro CAS:
183364-82-1
Poids moléculaire :
271.21
Numéro MDL:
MFCD00673967
Code UNSPSC :
12352200
ID de substance PubChem :
329825266
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

powder

Conditions de stockage

desiccated

Couleur

white to beige

Solubilité

H2O: >5 mg/mL

Température de stockage

room temp

Chaîne SMILES 

NC(C1CC1)(C(O)=O)c2ccc(cc2)P(O)(O)=O

InChI

1S/C11H14NO5P/c12-11(10(13)14,7-1-2-7)8-3-5-9(6-4-8)18(15,16)17/h3-7H,1-2,12H2,(H,13,14)(H2,15,16,17)

Clé InChI

IGODGTDUQSMDQU-UHFFFAOYSA-N

Actions biochimiques/physiologiques

(R,S)-α-Cyclopropyl-4-phosphonophenylglycine (CPPG) can be used in combination with scopolamine to treat the depressive disorder.
CPPG is a potent group II/III metabotropic glutamate receptor antagonist, with approximately 20-fold selectivity for mGlu group III over group II (IC50 values of 2.2 and 46.2 nM respectively).

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Kouji Fukuyama et al.
Biomolecules, 9(6) (2019-06-20)
Pharmacological mechanisms of gold-standard antipsychotics against treatment-refractory schizophrenia, such as clozapine (CLZ), remain unclear. We aimed to explore the mechanisms of CLZ by investigating the effects of MK801 and CLZ on tripartite synaptic transmission in the thalamocortical glutamatergic pathway using
Emmanuel Dornier et al.
Nature communications, 8(1), 2255-2255 (2017-12-23)
The role of glutaminolysis in providing metabolites to support tumour growth is well-established, but the involvement of glutamine metabolism in invasive processes is yet to be elucidated. Here we show that normal mammary epithelial cells consume glutamine, but do not
Mohaddeseh Ebrahimi-Ghiri et al.
Physiology & behavior, 224, 113034-113034 (2020-07-01)
Clinical trials have revealed that the muscarinic receptor antagonist scopolamine produces a fast and potent antidepressant response. However, the anticholinergic adverse effects and the risk of psychosis at higher doses limit the widespread clinical use of scopolamine. Combination therapy of
Sinead E Shortall et al.
Molecular neurobiology, 57(8), 3439-3457 (2020-06-14)
Despite several compounds entering clinical trials for the negative and cognitive symptoms of schizophrenia, few have progressed beyond phase III. This is partly attributed to a need for improved preclinical models, to understand disease and enable predictive evaluation of novel
Chantalle Briggs et al.
Neuropharmacology, 154, 50-60 (2018-12-27)
Sleep/wake states are controlled by sleep- and wake-promoting systems, and transitions between states are thought to be regulated by their reciprocal inhibition and homeostatic sleep need. Orexin neurons are known to promote wake maintenance and stabilize the sleep/wake switch. Thus
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