G7384

Gallic acid

97.5-102.5% (titration)

• Synonyme(s) : 3,4,5-Trihydroxybenzoic acid
• Formule linéaire : (HO)₃C₆H₂CO₂H
• Numéro CAS: 149-91-7
• Poids moléculaire : 170.12
• Numéro Beilstein : 2050274
• Numéro CE : 205-749-9
• Numéro MDL: MFCD00002510
• Code UNSPSC : 12352205
• ID de substance PubChem : 24895304
• Nomenclature NACRES : NA.25

Propriétés

• Source biologique: plant fruit
• Pureté: 97.5-102.5% (titration)
• Forme: powder
• Technique(s): HPLC: suitable
• Couleur: white to beige
• Pf: 251 °C (dec.) (lit.)
• Solubilité: ethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Adéquation: suitable for UV spectrophotometry and general use; suitable for absorption spectrum analysis
• Application(s): agriculture; metabolomics; microbiology; vitamins, nutraceuticals, and natural products; vitamins, nutraceuticals, and natural products
• Chaîne SMILES: OC(=O)c1cc(O)c(O)c(O)c1
• InChI: 1S/C7H6O5/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1-2,8-10H,(H,11,12)
• Clé InChI: LNTHITQWFMADLM-UHFFFAOYSA-N

Description

Description générale

Gallic acid, also known as 3,4,5-Trihydroxybenzoic acid, is a natural polyhydroxyphenolic compound commonly found in many fruits and plants, including grapes, tea, and oak bark, either in the free acid form or esterified as gallotannins and ellagitannins. Existing research suggests that this plant-derived metabolite is an astringent, a cyclooxygenase-2 (COX-2) and histone acetyltransferase inhibitor, and an apoptosis inducer with various biological activities. These activities include antioxidant, antifungal, gastroprotective, neuroprotective, cardioprotective, antimicrobial, anti-inflammatory, anti-tumor, anti-tyrosinase, and anticancer effects.

Application

Gallic acid has been used:

• as a standard for the quantification of extractable phenolics by external calibration
• as a standard to determine the total tannin content of oak root powder using the Folin-Ciocalteu method
• as a phenolic acid to study it′s in vitro antiviral, antibacterial, cytotoxicity and antifungal activities

Gallic acid is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical and biochemical research.

Actions biochimiques/physiologiques

Gallic acid is a water soluble phenolic acid present in grapes and in the leaves of many plants. Gallic acid esters, such as tannins, catechin gallates and aliphatic gallates are potent antioxidants in vitro. However, gallic acid itself also appears to have antioxidant, anticarcinogenic and antiangiogenic activity in vitro.

Caractéristiques et avantages

• High quality compound suitable for multiple research applications
• Compatible with HPLC and mass spectrometry techniques

Autres remarques

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Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves