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B8400

Sigma-Aldrich

Monoclonal Anti-Bovine IgG2 antibody produced in mouse

clone BG2-7, ascites fluid

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About This Item

Numéro MDL:
MFCD00164545
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46

Source biologique

mouse

Conjugué

unconjugated

Forme d'anticorps

ascites fluid

Type de produit anticorps

secondary antibodies

Clone

BG2-7, monoclonal

Contient

15 mM sodium azide

Technique(s)

capture ELISA: suitable
dot blot: suitable
indirect ELISA: 1:1,000
western blot: suitable

Isotype

IgG1

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Description générale

The IgG class antibodies contain two subclasses, IgG1 and IgG2, which have antigenic differences in the Fc portion of the heavy chains. Monoclonal Anti-Bovine IgG2 (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes of an immunized mouse.

Immunogène

Purified bovine IgG

Application

Monoclonal Anti-Bovine IgG2 antibody has been used in:
  • western blot
  • enzyme linked immunosorbent assay (ELISA)
  • dot blot assay

Actions biochimiques/physiologiques

Bovine IgGs are glycoprotein antibodies that regulate immune responses in herds. These antibodies inhibit TLR5 activation upon immunization with native H7 flagellin. Bovine IgG levels can be used for the detection of Johne′s disease and milk adulteration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Measurement of bovine IgG by indirect competitive ELISA as a means of detecting milk adulteration
Hurley IP, et al.
Journal of Dairy Science, 87(3), 543-549 (2004)
Detection of Bovine IgG Isotypes in a PPA-ELISA for Johne's Disease Diagnosis in Infected Herds
Fernandez B, et al.
Veterinary Medicine International, 2012 (2012)
Macarena Sarli et al.
PloS one, 15(2), e0229301-e0229301 (2020-02-23)
Anaplasma marginale is the most prevalent tick-borne livestock pathogen with worldwide distribution. Bovine anaplasmosis is a significant threat to cattle industry. Anaplasmosis outbreaks in endemic areas are prevented via vaccination with live A. centrale produced in splenectomized calves. Since A.
Tom N McNeilly et al.
Vaccine, 28(5), 1412-1421 (2009-11-21)
Systemic immunization of cattle with H7 flagellin results in induction of both H7-specific IgA and IgG antibodies but only partially protects against subsequent colonization with Escherichia coli O157:H7. Recent studies indicate that anti-flagellin antibodies directed against TLR5 binding domains located

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