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AV100774

Sigma-Aldrich

Anti-FOXK2 (AB2) antibody produced in rabbit

IgG fraction of antiserum

Synonyme(s) :

Anti-Forkhead box K2

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

69 kDa

Espèces réactives

human

Concentration

0.5 mg - 1 mg/mL

Technique(s)

western blot: suitable

Numéro d'accès NCBI

NP_004505

Numéro d'accès UniProt

Q01167

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... FOXK2(3607)

Description générale

FOXK2 belongs to the mammalian forkhead transcription factor family and contains forkhead DNA-binding domain and an FHA domain at the N-terminal region.

Immunogène

Synthetic peptide directed towards the C terminal region of human FOXK2

Application

Anti-FOXK2 (AB2) antibody produced in rabbit is suitable for western blotting at a concentration of 2.5 μg/ml.

Actions biochimiques/physiologiques

FOXK2 plays an important regulatory role in AP-1 binding and AP-1 mediated gene expression. It has been identified as regulator of IL-2 transcription and is linked to cell cycle progression. FOXK2 reportedly binds to DNA containing G/T mismatches with high affinity.

Séquence

Synthetic peptide located within the following region: SASLPTKRHNGDQPEQPELKRIKTEDGEGIVIALSVDTPPAAVREKGVQN

Forme physique

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

C Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(17), 7739-7743 (1991-09-01)
Human immunodeficiency virus (HIV) gene expression is regulated by both general transcription factors and factors induced by activation of T lymphocytes such as NF-kappa B and the nuclear factor of activated T cells (NFAT). Within the HIV long terminal repeat
Zongling Ji et al.
Molecular and cellular biology, 32(2), 385-398 (2011-11-16)
The transcriptional control circuitry in eukaryotic cells is complex and is orchestrated by combinatorially acting transcription factors. Forkhead transcription factors often function in concert with heterotypic transcription factors to specify distinct transcriptional programs. Here, we demonstrate that FOXK2 participates in
Yoshito Fujii et al.
Journal of biochemistry, 147(5), 705-709 (2010-01-26)
DNA mismatch repair is an important mechanism in the prevention of mutations. We reported the existence in the HL60 cell line of a novel G/T-mismatch DNA-binding protein (nGTBP) requiring strict DNA sequences. In this report, we identify the FOXK2 transcription
Anett Marais et al.
The Journal of biological chemistry, 285(46), 35728-35739 (2010-09-03)
Several mammalian forkhead transcription factors have been shown to impact on cell cycle regulation and are themselves linked to cell cycle control systems. Here we have investigated the little studied mammalian forkhead transcription factor FOXK2 and demonstrate that it is

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