05130

L-Alanine

≥99.0% (NT)

• Synonyme(s) : (S)-2-Aminopropionic acid, L-α-Aminopropionic acid
• Formule empirique (notation de Hill): C₃H₇NO₂
• Numéro CAS: 56-41-7
• Poids moléculaire : 89.09
• Numéro Beilstein : 1720248
• Numéro CE : 200-273-8
• Numéro MDL: MFCD00064410
• Code UNSPSC : 12352209
• eCl@ss : 32160406
• ID de substance PubChem : 329747640
• Nomenclature NACRES : NA.26

Propriétés

• Pureté: ≥99.0% (NT)
• Forme: powder or crystals
• Activité optique: [α]20/D +14.0±1°, c = 5% in 5 M HCl
• Impuretés: ≤0.3% foreign amino acids
• Résidus de calcination: ≤0.1% (as SO₄)
• Perte: ≤0.1% loss on drying, 110 °C
• Couleur: colorless to white
• Pf: 314.5 °C
• Solubilité: H₂O: soluble 89.1 g/l at 20 degrees c; diethyl ether: insoluble; ethanol: soluble (cold 80%)
• Traces d'anions: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤50 mg/kg
• Traces de cations: Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; NH₄⁺: ≤100 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• Application(s): detection; peptide synthesis
• Chaîne SMILES: C[C@H](N)C(O)=O
• InChI: 1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1
• Clé InChI: QNAYBMKLOCPYGJ-REOHCLBHSA-N

Description

Application

L-Alanine is used as a standard to determine absolute concentration of a protein within a mixture of other proteins measured with SI traceability.

Actions biochimiques/physiologiques

Alanine is a nonessential amino acid that plays a key role in the glucose-alanine cycle between muscle tissue and the liver. In amino acid-degrading tissues such as muscle, amino groups are pooled as glutamate by transamination reactions. The amino group of glutamate is transferred to pyruvate via alanine aminotransferase, forming alanine and α-ketoglutarate. The alanine is passed into the blood and transported to the liver. This reaction is reversed in the liver where pyruvate can be used in gluconeogenesis to form glucose, which may return to other tissues through the circulatory system. Increased alanine levels correlate with higher blood pressure, energy intake, cholesterol levels, and body mass index.

L-alanine has the ability to promote the expression of ferritin and antioxidant stress proteins, heme oxygenase-1 (HO-1).

Notes préparatoires

L-Alanine completely dissolves in water at a concentration of 89.1 g/l at 20°C to yield solution. It is also soluble in 80% ethanol and insoluble in ether.

Autres remarques

Preparation of 2-chloropropionic acid; Reduction of derivatives to the aldehyde

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)